Cart
sales@molnova.com
BGT226 free base
CAS No. 915020-55-2
BGT226 free base ( NVP-BGT226 )
Catalog No. M24960 CAS No. 915020-55-2
Bgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 104 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 390 | In Stock |
|
| 50MG | 574 | In Stock |
|
| 100MG | 803 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBGT226 free base
-
NoteResearch use only, not for human use.
-
Brief DescriptionBgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
-
DescriptionBgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
-
SynonymsNVP-BGT226
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3Kα; PI3Kβ; PI3Kγ; mTOR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number915020-55-2
-
Formula Weight534.5
-
Molecular FormulaC28H25F3N6O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCN(c(cnc(c1c2)ccc2-c(cc2)cnc2OC)c1N1c(cc2)cc(C(F)(F)F)c2N2CCNCC2)C1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Markman B , Tabernero J , Krop I , et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors[J]. Annals of Oncology Official Journal of the European Society for Medical Oncology, 2012, 23(9):2399.
molnova catalog
related products
-
GNE-477
A potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.
-
CL27c
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay.
-
GDC-0326
A potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM; displays 133, 20 and 33-fold selectivity over PI3Kβ, PI3Kδ and PI3Kγ, respectively.
